The Pharmacokinetics Module helps you find all the relevant data on your drug candidate, which means you can make better informed assessments and decisions. Included in this module;

• Unprecedented access to preclinical and clinical exposure data extracted from the entire history of FDA Approval Packages and EMA documents.
• Hundreds of thousands of pharmacokinetic, preclinical and clinical exposure data searchable and filterable in one platform.

Extracted data from more than 1.5 million pages, from:

• FDA Approval Packages (1992 to present).
• FDA Classic Collection (1938 to 1991).
• EMA EPARS (1995 to present).

All of these pharmacokinetic parameters can be searched, filtered or sorted under multiple experimental conditions.

With access to the wealth of data included in the Pharmacokinetics Module, you can:

• Gain competitive advantages: e.g. find out how to deliver a drug better than your competitors and identify competitive opportunities for any drug class based on your proprietary delivery methods or formulations.
• Create modelling sets: Model therapeutic windows on new drug projects earlier and more effectively than ever before and model the effects of different chemical substructures or active groups on exposure properties.
• Make drug-development-project risk assessments: e.g. can this drug be properly delivered at a safe dose?
• Understand potential pharmacokinetic responses: e.g. food effects, concomitant drugs, co-morbidities and demographic effects.
• Compare internally generated exposure data with drugs sharing similarities in class, chemistry or targets.

What does a typical search look like?

We know that it can take great amounts of time to find all the right data, even on a single drug pharmacokinetic parameter. The Pharmacokinetics Module helps you answer the kind of research questions that you deal with on a daily basis, saving potentially months of painstaking research.

Example: Can I find a drug in any class with T1/2 of more than five hours and food-effect data?

Step 1: Searching for anticonvulsants that have a T1/2 of more than five hours and filtering for food-effect data returns from FDA Approval Packages and EMA documents.

Step 2: You can then click through from the search results to view the full study that you are interested in. In this example, we have clicked "View Full Study" for carbamazepine.

Step 3: You can then refine your search using parameter filters, such as "species".

Step 4: You can also filter your search based on biotransformation data to retrieve documents reporting enantiomeric ratio, metabolic transformation, metabolic ratio and metabolic stability. Please note the numerical value of these pharmacokinetic parameters that have been excerpted by our indexers.

The absorption filter can also be used to refine your search by other pharmacokinetic parameters such as bioavailability and concentration data.

 

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